Hyperuricosuria | Animal Genetics



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Hyperuricosuria (HUU)


Dogs with this genetic mutation metabolize waste products as uric acid in their urine. The uric acid forms into hard stones in the bladder, causing pain and inflammation as the stone moves through the urinary tract.


A dog that has difficulty urinating or appears to have an inflamed bladder may have HUU. Other signs can include blood in the urine and frequent urination. If the dog is unable to pass the urate stones without medical intervention, surgery may be required to remove them. And if the urinary tract is blocked, the condition can be life threatening. Even in the best case scenario, HUU is uncomfortable and painful for the dog.

The mutation is autosomal recessive. Both parents will need to be carriers of the mutation to pass it on to their offspring. Carriers will not show any symptoms of HUU and even affected dogs may not show any signs, so it is important to test dogs for HUU prior to breeding.

Sample Type:

Animal Genetics accepts buccal swab, blood, and dewclaw samples for testing. Sample collection kits are available and can be ordered at Canine Test Now.

Test Is Relevant to the Following Breeds:

Hyperuricosuria can be tested for in any breed, but is more prevalent in the following breeds:


All Breeds including, American Bulldog, Bulldog, French Bull Dog, American Pitbull Terrier, American Staffordshire Terrier, Australian Shepherd, Black Russian Terrier, Bulldog, Catahoula Leopard Dog, Dalmatian, German Shepherd, Giant Schnauzer, Jack Russel/Parsons Terrier, Labrador Retriever, Large Munsterlander, South African Boerboel, Vizsla and Weimaraner, Hungarian Vizsla.


Animal Genetics offers DNA testing for Hyperuricosuria. The genetic test verifies the presence of the Hyperuricosuria mutation and presents results as one of the following:

HUU/HUU Affected The dog carries two copies of the mutant gene and is homozygous for Hyperuricosuria. The dog is likely to be affected by Hyperuricosuria and will always pass a copy of the mutation to its offspring.
HUU/n Carrier Both the normal and mutant copies of the gene detected. Dog is a carrier for the Hyperuricosuria mutation and can pass on a copy of the defective gene to its offspring.
n/n Clear Dog tested negative for the Hyperuricosuria mutation and will not pass on the defective gene to its offspring.